NIDCR Issues Latest Newsletter
The National Institute of Dental and Craniofacial Research (NIDCR) has issued its latest newsletter, which can be read below.
NIDCR's quarterly newsletterIn this issue:
June 5: NIH Barmes Lecture Returns with Ambassador John Nkengasong
Resolution Honoring NIDCR’s 75th Anniversary Passed in U.S. Senate
Recording Now Available: Sealant Implementation Webinar
Nadine Samara Finds Her Calling at NIH
Save the Date: NIH Professional Development & Networking Workshop — September 24-25
NIH To Increase Pay Levels for Pre- and Postdoctoral Scholars at Grantee Institutions
Interested in Becoming an NIDCR Trainee? Apply Now
Healthy Mouth, Healthy Body
Facing Cancer Head-On
Gum Cells May Trigger Inflammation, Gum Disease
Gum Disease-Related Bacteria Tied to Colorectal Cancer
Topical Solution Halts Tooth Decay in Children
Bone Marrow Cells Reveal Secret Weapon to Battle Bacteria
Wrecking Cellular Recycling to Learn About Lung Cancer
The Perplexing Pancreas
UM Research Discovers New Way to Generate Human CartilageUniversity of Montana – April 10, 2024Scientists Identify Key Step in How Teeth Develop in the WombCedars-Sinai Medical Center – April 3, 2024New Resource for NIH-Affiliated Researchers: NIH Cloud Lab
NIH Guidance on Marking Changes in Resubmission Application
NIH Scientists Find Weak Points on Epstein-Barr Virus
NIH Launches Research Network To Evaluate Cancer Screening Technologies
Researchers Optimize Genetic Tests To Tackle Health Disparities
275 Million New Genetic Variants Identified
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The Fogarty International Center and NIDCR will co-host the 2024 David E. Barmes Global Health Lecture: Global HIV/AIDS Response: Then, Now, Future, by Ambassador John Nkengasong, Ph.D., U.S. Global AIDS Coordinator and Senior Bureau Official for Global Health Security and Diplomacy. The lecture will take place on Wednesday, June 5, from 1:00-2:00 p.m. ET in the Natcher Conference Center on the NIH campus and via videocast. 
With unanimous support, the U.S. Senate introduced and passed a resolution recognizing NIDCR’s 75th anniversary. The resolution recognizes the institute’s role in improving the dental, oral, and craniofacial health of the nation through research, training, and the dissemination of health information. 
In observance of National Children’s Dental Health Month, NIDCR and the American Dental Association jointly held a webinar featuring a panel discussion on the current landscape of dental sealant uptake and implementation for prevention of caries in children, particularly among those from underrepresented groups. 
In recognition of Women’s History Month, the NIH Record published a profile on NIDCR Stadtman Tenure-Track Investigator Nadine Samara, Ph.D., who studies the sugars that bacteria make and use to evade the host immune system. In the profile, she stressed the importance of making people feel safe, supported, and mentored in her lab. 
The 2024 NIH Diversity Supplement Professional Development and Networking Workshop will take place September 24-25, bringing together scholars from NIH institutes and centers, including NIDCR. The virtual event will demystify the NIH grant process and allow scholars to meet NIH program staff, present their research, and network. 
NIH will increase annual pay levels for research trainees who receive the Ruth L. Kirschstein National Research Service Awards at NIH-funded external institutions. The increase applies to more than 17,000 predoctoral and postdoctoral scholars and includes additional funds for 
For the last 40 years, NIDCR has supported research on the biological links between the mouth and the rest of the body, commonly known as the “oral-systemic connection.” In that time, scientists have unveiled a multitude of connections between oral diseases such as gum disease and tooth decay, and conditions like diabetes, dementia, cardiovascular disease, preterm birth, AIDS, and cancers, among others. 
We need better ways to treat and prevent head and neck cancers, which often go undetected until they’re quite advanced. From cancer vaccines and tumor-killing therapies to computer algorithms that map suspicious growths in the mouth, ongoing NIDCR-supported research aims to bring better care to patients with head and neck cancer. 
Aside from their role as a protective physical barrier, epithelial cells that line the mouth and gums may directly activate the immune system, triggering chronic inflammation that leads to gum disease. A study led by NIDCR Associate Scientific Director Niki Moutsopoulos, D.D.S., Ph.D., provides evidence that these cells may play a bigger role in disease development than previously thought. 
Scientists identified a specific subtype of Fusobacterium nucleatum — a type of bacteria implicated in gum disease — that may promote the growth of colorectal tumors. The study, which was partly funded by NIDCR, suggests that therapies targeting these bacteria in tumors could help reduce the severity of some colorectal cancers. 
A topical liquid, silver diamine fluoride (SDF), can stop tooth decay in young children, according to a clinical trial funded by NIDCR. SDF can be easily and painlessly swabbed onto cavities and could be a potential tool for improving children’s oral health. 
NIH’s I am Intramural Blog recently featured the work of NIDCR Senior Investigator Eva Mezey, M.D., Ph.D., and her colleagues, who discovered that bone marrow stem cells make hepcidin, a small molecule that can kill bacteria and tame overreactive immune responses caused by inflammation. 
In a SciBites video from the NIH Intramural Research Program, Maya English, a postbaccalaureate research fellow in the lab of NIDCR’s Achim Warner, Ph.D., described her research on how protein recycling goes awry in certain lung cancers. What she learns may inform treatments for diseases that arise from faulty recycling. 
The NIH Catalyst recently highlighted investigators, including NIDCR’s Shmuel Muallem, Ph.D., who are using multifaceted approaches to better understand pancreatic disease. Dr. Muallem’s lab is exploring how drugs approved for cystic fibrosis might be repurposed to correct dysfunctional fluid secretion in mouse models of pancreatitis and Sjögren’s disease. 
NIH-affiliated researchers and students can receive up to 90 days of free access to NIH Cloud Lab, a self-paced, interactive, cloud-based training program and commercial cloud service. Researchers and students can explore cloud capabilities for research and access bioinformatic tutorials and data sets in a secure, NIH-approved environment. 
Starting May 25, 2024, markups should not be used to identify changes in grant resubmission applications. Applicants should include in the Introduction attachment a summary of all substantial changes and a response to weaknesses raised by the prior review. 
By studying the interactions between lab-generated monoclonal antibodies and an Epstein-Barr virus (EBV) protein, researchers at the National Institute of Allergy and Infectious Diseases have uncovered new details that could aid treatment and vaccine development. EBV can reside in cell linings of the throat, sometimes leading to nose and throat cancer. 
The newly launched Cancer Screening Research Network will evaluate the benefits and harms of promising new technologies for cancer screening and determine how to incorporate them into the standard of care. This clinical trials network will support the Biden-Harris administration’s Cancer Moonshot program. 
A recent NIH-funded study has devised new ways to improve a genetic testing method called a polygenic risk score to more accurately assess disease risk regardless of genetic ancestry. Genomic datasets used to calculate scores often overrepresent people of European ancestry, which can contribute to health disparities. 
Researchers have discovered more than 275 million previously unreported genetic variants, which were identified from data shared by nearly 250,000 participants of NIH’s All of Us Research Program. These results can help scientists better understand genetic influences on health and disease, especially in communities that have been left out of research in the past. 
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